What Are the Side Effects of Gabapentin?

In recent years, gabapentin has been studied, and it has become popular for use in treating certain mental health disorders, including addiction. It has been promoted by some as helpful in getting through detox and in avoiding relapse to substance abuse. On the other hand, there are some concerns about how the drug works and whether it, too, can become the focus of addiction.

This article will help you understand what gabapentin is and how this drug affects the individuals who use it.

What Is Gabapentin?

Originally, gabapentin – the generic version of a medication used in brand name prescriptions Neurontin and Horizant, among others – was developed as an anticonvulsant to treat epileptic seizures. A potent drug for nervous system issues, it can also be used for restless leg syndrome and various kinds of nerve-based pain, as described on Drugs.com.

The action of gabapentin is not fully understood, but what is known is that it seems to stabilize brain activity through the release of certain neurotransmitters, including those in the GABA system, which can lead to its anticonvulsant and pain control capabilities.

However, the drug does not bind to GABA or other neurotransmitter receptors in the brain, so it was originally thought that the drug would not be implicated in addiction.

Gabapentin for Mental Health Care

Gabapentin is used off-label to treat a variety of psychiatric disorders, such as anxiety and depression. In addition, several trials have been performed that show gabapentin can be useful in helping people in addiction treatment to detox, particularly in withdrawal from alcohol and other depressants, like benzodiazepines.

A study from JAMA Internal Medicine shows that people recovering from alcohol use disorder who used gabapentin were more likely to either fully abstain from or at least avoid heavy use of alcohol.

For those who took 900 mg of the drug:

  • 11.1% abstained completely.
  • 29.6% avoided heavy use.

For those who took 1800 mg, the results were even more dramatic:

  • 17% abstained
  • 44.7% were able to avoid heavy drinking

Another study from the American Journal of Drug and Alcohol Abuse demonstrated that gabapentin can help in treating addiction to benzodiazepines for people who are in methadone maintenance treatment for opioid addiction. Because benzodiazepines are highly addictive, this is thought to be a relatively safe option for helping to avoid further addiction complications in these individuals.

Side Effects of Gabapentin

Because gabapentin affects neurotransmitters that create a sense of sedation or relaxation in the body, the side effects are similar to those of depressants or alcohol. The National Library of Medicine’s Medline Plus includes a long list of side effects that can result from using gabapentin. These side effects include:

  • Drowsiness, tiredness or weakness, dizziness, or unsteadiness.
  • Headaches, memory issues, unusual thoughts, or anxiety.
  • Red or itchy eyes and double vision.
  • Ear pain and muscle or joint pain.
  • Digestive issues, increased appetite and weight gain, and heartburn.
  • Dry mouth, fever, and flu-like symptoms.

Gabapentin Addiction

Another side effect of gabapentin use that has been reported in some cases is the potential for addiction. An article from Medscape indicates several cases that appear to demonstrate behaviors associated with addiction in those who have taken long-term gabapentin. Most of the individuals discussed also had histories of substance misuse. Some admitted to using the drug to make other drugs, like methadone, more potent.

Withdrawal symptoms also occurred for a number of these people when gabapentin use was stopped. These symptoms indicate that the body has become dependent on the drug, which contributes to addiction.

The mechanism through which gabapentin might cause addiction is not known. As stated above, it does not appear to interact with the main areas of brain chemistry that are understood to contribute to addiction. More research is needed to determine how addiction to the drug is occurring.

Nevertheless, it is apparent that addiction is possible, particularly for those who have a history of or tendency toward addiction. For this reason, care should be taken in using the drug if these conditions exist.

Withdrawal Symptoms

Determining whether an individual has become addicted to gabapentin can be done by assessing withdrawal symptoms (side effects of stopping use of the drug). The Medscape article indicates that these can include:

  • Disorientation or confusion.
  • Irregular heartbeat.
  • Excitability and agitation.
  • Trembling.
  • Sweating.

These symptoms can be uncomfortable enough to require hospitalization for some individuals to manage the worst elements of detox from the drug.

According to Mayo Clinic, it is also risky to stop taking gabapentin – or any anti-epileptic drug – abruptly, as this can lead to increased seizures. Stopping gabapentin for any reason should be done under the care of a professional who has experience with gabapentin use and misuse.

Getting Help for Gabapentin Addiction

For the reasons above, gabapentin use should not be initiated without the help of a doctor or other medical professional who understands the risks of using this drug. Working with a medical professional can help control or manage side effects that the individual might experience.

Medical support can also make sure that any serious side effects are noted immediately, and the individual can be taken off the drug safely without the risk of more serious withdrawal symptoms and side effects.

When receiving gabapentin for addiction treatment, it is important to follow the prescription instructions accurately to decrease the chances of developing an addiction. Staying in close collaboration with the treating professional about potential issues regarding addiction to gabapentin is also important.

Finally, if addiction to gabapentin – or the potential for addiction – is suspected, there are other options to treat alcohol and benzodiazepine addiction and other mental health conditions. These treatment options are supported by research as effective in helping individuals get control over substance misuse and avoid relapse back to use in the future.

Finding a research-based, certified, and experienced treatment program is the first step toward obtaining successful individualized treatment for addiction. Recovery First in Hollywood, Florida, is one of the leading drug and alcohol rehabs in the Miami area. Our clinical team has years of experience in the field of addiction.

To start the admissions process, call a friendly admissions navigator at . You can also confidentially now. Recovery is possible, and we’re here to help.

The Price of Not Getting Help
When contemplating the costs of addiction treatment for yourself, child, or loved one, consider the costs, or consequences, of “things as they are now.” What would happen if the substance abuse or addiction continued? Contact Recovery First, and we will help you or your loved one get the treatment needed to stop the dangerous, progressive effects of addiction.